Antioxidant Genetic Variants Modify Echocardiography Indices in Long COVID.
Milika AsaninMarko ErcegovacGordana KrljanacTatjana DjukicVesna CoricDjurdja JeroticMarija Plješa-ErcegovacMarija MaticIvana MiloševićMihajlo ViduljevicGoran StevanovicJovan T RaninTatjana SimićZoran BukumiricAna Savic RadojevicPublished in: International journal of molecular sciences (2023)
Although disturbance of redox homeostasis might be responsible for COVID-19 cardiac complications, this molecular mechanism has not been addressed yet. We have proposed modifying the effects of antioxidant proteins polymorphisms (superoxide dismutase 2 ( SOD2 ), glutathione peroxidase 1 ( GPX1 ), glutathione peroxidase 3 ( GPX3 ) and nuclear factor erythroid 2-related factor 2, ( Nrf2 )) in individual susceptibility towards the development of cardiac manifestations of long COVID-19. The presence of subclinical cardiac dysfunction was assessed via echocardiography and cardiac magnetic resonance imaging in 174 convalescent COVID-19 patients. SOD2, GPX1 , GPX3 and Nrf2 polymorphisms were determined via the appropriate PCR methods. No significant association of the investigated polymorphisms with the risk of arrhythmia development was found. However, the carriers of variant GPX1 *T, GPX3 *C or Nrf2 *A alleles were more than twice less prone for dyspnea development in comparison with the carriers of the referent ones. These findings were even more potentiated in the carriers of any two variant alleles of these genes (OR = 0.273, and p = 0.016). The variant GPX alleles were significantly associated with left atrial and right ventricular echocardiographic parameters, specifically LAVI, RFAC and RV-EF ( p = 0.025, p = 0.009, and p = 0.007, respectively). Based on the relation between the variant SOD2 *T allele and higher levels of LV echocardiographic parameters, EDD, LVMI and GLS, as well as troponin T ( p = 0.038), it can be proposed that recovered COVID-19 patients, who are the carriers of this genetic variant, might have subtle left ventricular systolic dysfunction. No significant association between the investigated polymorphisms and cardiac disfunction was observed when cardiac magnetic resonance imaging was performed. Our results on the association between antioxidant genetic variants and long COVID cardiological manifestations highlight the involvement of genetic propensity in both acute and long COVID clinical manifestations.
Keyphrases
- left ventricular
- left atrial
- sars cov
- coronavirus disease
- oxidative stress
- hypertrophic cardiomyopathy
- cardiac resynchronization therapy
- mitral valve
- heart failure
- acute myocardial infarction
- magnetic resonance imaging
- aortic stenosis
- nuclear factor
- pulmonary hypertension
- hydrogen peroxide
- respiratory syndrome coronavirus
- genome wide
- atrial fibrillation
- toll like receptor
- mycobacterium tuberculosis
- immune response
- amyotrophic lateral sclerosis
- anti inflammatory
- magnetic resonance
- palliative care
- dna methylation
- hepatitis b virus
- liver failure
- transcatheter aortic valve replacement
- contrast enhanced
- genome wide identification