Development and evaluation of a bovine lung-on-chip (bLOC) to study bovine respiratory diseases.
Diane Frances LeeClare L ThompsonRonald E BaynesHiroko EnomotoGeof W SmithMark Andrew ChambersPublished in: In vitro models (2022)
A co-culture model of the bovine proximal airway was successfully generated, with potential to replace in vivo experimentation. With further optimisation and characterisation, the bLOC may be suitable to perform drug pharmacokinetic studies for bovine respiratory disease (BRD), and other applications.