Pediatric Neoplasms Presenting with Monocytosis.
Jacob R GreenmyerMira A KohorstPublished in: Current hematologic malignancy reports (2021)
DNA hypermethylation studies have demonstrated consistently that methylation is related to disease severity. Increasing understanding of methylation in JMML may open the door to novel therapies, such as DNA methyltransferase inhibitors. The PI3K/AKT/MTOR, JAK/STAT, and RAF/MEK/ERK pathways are being investigated as therapeutic targets for JMML. Future therapy for JMML will be driven by an increased understanding of pathobiology. Targeted therapeutic approaches hold potential for improving outcomes in patients with JMML.
Keyphrases
- circulating tumor
- cell free
- single molecule
- dna methylation
- genome wide
- pi k akt
- signaling pathway
- minimally invasive
- current status
- nucleic acid
- case report
- gene expression
- type diabetes
- circulating tumor cells
- skeletal muscle
- young adults
- drug delivery
- climate change
- weight loss
- glycemic control
- high speed
- childhood cancer