Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma.

Harry Ho Man NgRen Yuan LeeSiting GohIsabel Shu Ying TayXinru LimBernett LeeValerie ChewHuihua LiBenedict TanSherlly LimJeffrey Chun Tatt LimBijin AuJosh Jie Hua LohSahil SarafJohn Edward ConnollyTracy LohWei Qiang LeowJoycelyn Jie Xin LeeHan Chong TohFabio MalavasiSer Yee LeePierce ChowEvan W NewellSu Pin ChooDavid TaiJoe YeongTony Kiat Hon Lim

Published in: Journal for immunotherapy of cancer (2021)

A high proportion of CD38+ cells, determined by IHC, predicts response to ICB and is associated with superior mPFS and OS in advanced HCC.

Keyphrases

induced apoptosis
cell cycle arrest
nk cells
oxidative stress
signaling pathway
cell death
cell proliferation