Repurposing of Trimetazidine for Amyotrophic Lateral Sclerosis: a study in SOD1G93A mice.

Silvia ScaricamazzaIllari SalvatoriSusanna AmadioValentina NesciAlessio TorcinaroGiacomo GiacovazzoAniello PrimianoMichela GlorianiNiccolò CandeliseLuisa PieroniJean-Philippe LoefflerFrederique RenèCyril QuessadaTesfaye W TeferaHao WangFrederik J SteynShyuan T NgoGabriella DobrowolnyElisa LeporeAndrea UrbaniAntonio MusaròCinzia VolontéElisabetta FerraroRoberto CoccurelloCristiana ValleAlberto Ferri

Published in: British journal of pharmacology (2021)

In SOD1G93A mice, therapeutic effect of Trimetazidine is underpinned by its action on mitochondrial function in skeletal muscle and spinal cord.

Keyphrases

amyotrophic lateral sclerosis
skeletal muscle
spinal cord
high fat diet induced
insulin resistance
spinal cord injury
neuropathic pain
wild type
metabolic syndrome