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AAZTA: An Ideal Chelating Agent for the Development of 44 Sc PET Imaging Agents.

Gábor NagyDezső SzikraGyörgy TrencsényiAnikó FeketeIldikó GaraiArianna M GianiRoberto NegriNorberto MasciocchiAlessandro MaiocchiFulvio UggeriImre TóthSilvio AimeGiovanni Battista GiovenzanaZsolt Baranyai
Published in: Angewandte Chemie (International ed. in English) (2017)
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
Keyphrases
  • pet imaging
  • positron emission tomography
  • ionic liquid
  • photodynamic therapy
  • type diabetes
  • high fat diet induced
  • metabolic syndrome
  • adipose tissue