Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of Escherichia coli and Klebsiella pneumoniae harbouring serine- and New Delhi metallo-β-lactamases.

Kun FengNan JiaPeijuan ZhuSerubbabel SyYanfei LiuDandan DongShixing ZhuJiayuan ZhangYuwei LiuFrederico S MartinsHugh GongZhihua LvMingming YuSherwin K B SyYuanqi Zhu

Published in: The Journal of antimicrobial chemotherapy (2021)

Effective antimicrobial combination optimized the PD parameters measuring selection for emergent mutants by increasing fT>MPC and reducing fTMSW.

Keyphrases

klebsiella pneumoniae
escherichia coli
multidrug resistant
gram negative
wild type
staphylococcus aureus
biofilm formation
protein kinase
pseudomonas aeruginosa
cystic fibrosis