Hepcidin resistance in dysmetabolic iron overload.
Raffaela RamettaPaola DongiovanniSerena PelusiPaolo FrancioneFederica IuculanoVittorio BorroniErika FattaAnnalisa CastagnaDomenico GirelliSilvia FargionLuca Vittorio ValentiPublished in: Liver international : official journal of the International Association for the Study of the Liver (2016)
Dysmetabolic iron overload syndrome is associated with a subtle impairment in the ability of the iron hormone hepcidin to restrain iron absorption following an iron challenge, suggesting a hepcidin resistance state. Further studies are required to better characterize the molecular mechanism underpinning this new iron metabolism alteration.
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