Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer.
Jagadeesh K VenkatesanWeikun MengAna Rey-RicoGertrud SchmittSusanne Speicher-MentgesCéline Falentin-DaudréAmélie LerouxHenning MadryVéronique MigonneyMagali CucchiariniPublished in: Pharmaceutics (2020)
These findings show the benefits of targeting patients' bone marrow via PCL film-guided therapeutic rAAV (sox9) delivery as an off-the-shelf system for future strategies to enhance cartilage repair in translational applications.
Keyphrases
- bone marrow
- mesenchymal stem cells
- transcription factor
- end stage renal disease
- stem cells
- newly diagnosed
- ejection fraction
- endothelial cells
- chronic kidney disease
- room temperature
- genome wide
- cell proliferation
- reduced graphene oxide
- cancer therapy
- gold nanoparticles
- dna methylation
- extracellular matrix
- drug delivery
- patient reported