TRPA1 and TRPV1 contribute to propofol-mediated antagonism of U46619-induced constriction in murine coronary arteries.

Pritam SinharoyIan N BratzSayantani SinhaLoral E ShowalterSpencer R AndreiDerek S Damron

Published in: PloS one (2017)

TRPA1 and TRPV1 appear to contribute to the propofol-mediated antagonism of U46619-induced constriction in murine coronary microvessels that involves activation of NOS and BKCa.

Keyphrases

neuropathic pain
coronary artery disease
coronary artery
high glucose
diabetic rats
drug induced
spinal cord
heart failure
oxidative stress
nitric oxide synthase
blood flow