PRF1 mutation alters immune system activation, inflammation, and risk of autoimmunity.
Carlo SidoreValeria OrrùEleonora CoccoMaristella SteriJamie Rj InshawMaristella PitzalisAntonella MulasStuart McGurnaghanJessica FrauEleonora PorcuFabio BusoneroMariano DeiSandra LaiGabriella SoleFrancesca VirdisValentina SerraFausto PoddieAlessandro DelitalaMichele MarongiuFrancesca DeiddaMauro PalaMatteo FlorisMarco MasalaSuna Onngut-GumuscuCatherine C RobertsonLidia LeoniAnnapaola FrongiaMaria Rossella RicciardiMargherita ChessaNazario OllaMario LovicuAnnalisa LoizeddaAndrea MaschioLuisa MereuPaola FerrignoNicolo CurreliLenuta BalaciFrancesco LoiLiana Ap FerreliMaria Grazia PiliaAntonello PaniMaria Giovanna MarrosuGoncalo R AbecasisStephen S RichHelen ColhounJohn A ToddDavid SchlessingerEdoardo FiorilloFrancesco CuccaMagdalena ZoledziewskaPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
Our results indicate opposing contributions of the cytotoxic T-cell compartment to MS and T1D pathogenesis.