Weight Change and Incident Distal Colorectal Adenoma Risk in the PLCO Cancer Screening Trial.
Shisi HeSonja I BerndtAndrew T KunzmannCari M KitaharaWen-Yi HuangKathryn Hughes BarryPublished in: JNCI cancer spectrum (2022)
Weight loss in adulthood was associated with reduced adenoma risk, particularly for those who were overweight or obese, whereas weight gain greater than 3 kg/5 years increased risk. Findings underscore the importance of healthy weight maintenance throughout adulthood in preventing colorectal adenoma.
Keyphrases
- weight loss
- weight gain
- bariatric surgery
- body mass index
- roux en y gastric bypass
- birth weight
- gastric bypass
- depressive symptoms
- adipose tissue
- clinical trial
- metabolic syndrome
- papillary thyroid
- glycemic control
- obese patients
- type diabetes
- early life
- squamous cell
- minimally invasive
- squamous cell carcinoma
- lymph node metastasis
- young adults
- skeletal muscle
- insulin resistance
- preterm birth