Discovery and Validation of Survival-Specific Genes in Papillary Renal Cell Carcinoma Using a Customized Next-Generation Sequencing Gene Panel.
Jia HwangSeokhwan BangMoon-Hyung ChoiSung-Hoo HongSae Woong KimHye Eun LeeJi Hoon YangUn Sang ParkYeong Jin ChoiPublished in: Cancers (2024)
We discovered and verified genes specific for the survival of PRCC patients in the TCGA-KIRP and Korean-KIRP databases. The survival gene signature, including PCSK2 commonly obtained from the 40 gene signature of TCGA and the 10 gene signature of the Korean database, is expected to provide insight into predicting the survival of PRCC patients and developing new treatment.
Keyphrases
- single cell
- genome wide
- end stage renal disease
- genome wide identification
- copy number
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- free survival
- emergency department
- small molecule
- machine learning
- transcription factor
- genome wide analysis
- gene expression
- deep learning
- cell free
- clinical evaluation