Receptor for Advanced Glycation End Products is Involved in Platelet Hyperactivation and Arterial Thrombosis during Chronic Kidney Disease.

Jérémy OrtillonNathalie HézardKarim BelmokhtarCharlotte KaweckiChristine TerrynGuenter FritzAlexandre KauskotAnn Marie SchmidtPhilippe RieuPhilippe NguyenPascal MauriceFatouma Touré

Published in: Thrombosis and haemostasis (2020)

Our results show that CKD induces platelet hyperactivation, accelerates thrombus formation in a murine model of arterial thrombosis, and that RAGE deletion has a protective role. We propose that RAGE ligands binding to RAGE is involved in CKD-induced arterial thrombosis.

Keyphrases

chronic kidney disease
pulmonary embolism
end stage renal disease
diabetic rats
drug induced
oxidative stress