3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation.
Irini Skaripa-KoukelliDavid HautonJohn Walsby-TickleEloïse ThomasJoshua OwenAbirami LakshminarayananSarah AbleJames McCullaghRobert C CarlisleKatherine A VallisPublished in: Cancer & metabolism (2021)
Overall, MCT1-mediated metabolic perturbation in combination with radiotherapy is shown to be a promising strategy for the treatment of glycolytic tumors such as TNBC, overcoming the selectivity challenges of targeting glycolysis with glucose analogs.