Centella asiatica modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).
Dhaneshree Bestinee NaidooAnil Amichund ChuturgoonAlisa PhulukdareeKanive Parashiva GuruprasadKapaettu SatyamoorthyVikash SewramPublished in: BMC complementary and alternative medicine (2017)
In PBMC's and THP-1 cells, CLE proved to effectively modulate antioxidant activity, inflammatory cytokines and cell death. In THP-1 cells, CLE decreased pro-inflammatory cytokine levels whereas it increased anti-inflammatory cytokine levels which may alleviate cancer cachexia.