Gliclazide reduced oxidative stress, inflammation, and bone loss in an experimental periodontal disease model.

Aurigena Antunes de Araújo Helicarlos Batista de Morais Caroline Adisson Carvalho Xavier de Medeiros Gerly Anne de Castro Brito Paulo Marcos da Matta Guedes Sarah Hiyari Flávia Q Pirih Raimundo Fernandes de Araújo Júnior

Published in: Journal of applied oral science : revista FOB (2019)

This treatment decreased neutrophil and macrophage migration, decreased the inflammatory response, and decreased bone loss in rats with ligature-induced periodontitis.

Keyphrases

bone loss
oxidative stress
inflammatory response
diabetic rats
dna damage
adipose tissue
high glucose
induced apoptosis
ischemia reperfusion injury
drug induced
lps induced
toll like receptor
signaling pathway