Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis.
Yoshihiro HasegawaJennifer M FranksYusuke TanakaYasuaki UeharaDavid F ReadClaire R WilliamsSanjay R SrivatsanLori B PitstickNikolaos M NikolaidisCiara M ShaverHuixing WuJason C GardnerAndrew R OsterburgJane J YuElizabeth J KoprasSteven L TeitelbaumKathryn A Wikenheiser-BrokampCole TrapnellFrancis X McCormackPublished in: bioRxiv : the preprint server for biology (2023)
Silica induces the alveolar epithelium to reprogram recruited and resident pulmonary myeloid cells to become osteoclasts that contribute to pulmonary fibrosis.