The Effect of Early vs Delayed Initiation of Adalimumab on Remission Rates in Patients With Crohn's Disease With Poor Prognostic Factors: The MODIFY Study.

Gerassimos J MantzarisChristos ZeglinasAngeliki TheodoropoulouIoannis KoutroubakisEleni OrfanoudakiKonstantinos KatsanosDimitrios ChristodoulouGeorgios MichalopoulosMaria TzouvalaDimitrios MoschovisSpyridon MichopoulosEvanthia ZampeliKonstantinos SouflerisAnastasios IliasChristina ChatzievangelinouAntonios KyriakakisKonstantia AntachopoulouKonstantinos Karmiris

Published in: Crohn's & colitis 360 (2021)

Patients with CD with PPFs who received early vs delayed treatment with ADL achieved higher clinical response and remission rates. This effect was more pronounced in those patients who were bio-naive and steroid-dependent/refractory with concurrent extraintestinal manifestations than those who were not.

Keyphrases

prognostic factors
ulcerative colitis
rheumatoid arthritis
hiv infected
squamous cell carcinoma
locally advanced
combination therapy
rectal cancer
smoking cessation