Large-Scale Cancer Genomic Analysis Reveals Significant Disparities between Microsatellite Instability and Tumor Mutational Burden.
Jung Yoon ChoiKyong-Hwa ParkYeul Hong KimJason K SaHwa Jung SungYu-Wei ChenZhi-Shan ChenChao LiWanqing WenQingrun ZhangChristina E BaileyQuan LongJung Sun KimXingyi GuoPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2024)
These findings suggest that distinct or combined biomarkers should be considered for immunotherapy in human cancers because notable discrepancies exist between MSI-H and TMB-H across different cancer types.