Interest of exome sequencing trio-like strategy based on pooled parental DNA for diagnosis and translational research in rare diseases.
Frederic Tran Mau-ThemYannis DuffourdAntonio VitobelloAnge-Line BruelAnne-Sophie Denommé-PichonSophie NambotJulian DelanneSebastien MouttonArthur Sorlinnull nullVictor CouturierValentin BourgeoisMartin ChevarinCharlotte PoeAnne-Laure Mosca-BoidronPatrick CallierHana SafraouLaurence Olivier-FaivreChristophe PhilippeChristel Thauvin-RobinetPublished in: Molecular genetics & genomic medicine (2021)
Parental-pooling is an efficient alternative to trio-ES. It provides rapid segregation and extension to translational research while reducing the cost of parental and Sanger sequencing.