A novel formulation of zolpidem for direct nose-to-brain delivery: synthesis, encapsulation and intranasal administration to mice.
Tatiana N BorodinaIrina MarchenkoDaria TrushinaYulia VolkovaValerii ShirinianIgor ZavarzinEvgeny KondrakhinGeorgy KovalevMikhail KovalchukTatiana BukreevaPublished in: The Journal of pharmacy and pharmacology (2018)
The polyelectrolyte shell deposited together with zolpidem enhances the loading efficacy of the microcontainers. In vivo experiments on mice demonstrate increase in anxiolytic effect of zolpidem in microcontainers compared with upon intranasal administration of free medicine.