Genetic Heterogeneity of Esophageal Squamous Cell Carcinoma with Inherited Family History.

Wenwu HeXuefeng LengYanyu YangLin PengYang ShaoXue LiYongtao Han

Published in: OncoTargets and therapy (2020)

Our results identified mutation profiles in patients with familial and nonfamilial ESCC, and identified germline mutations in patients with positive history. TMB values may be informative for immunotherapy approaches in familial ESCC.

Keyphrases

early onset
single cell
dna repair
copy number
gene expression
oxidative stress
dna damage