A Population Pharmacokinetic Model Does Not Predict the Optimal Starting Dose of Tacrolimus in Pediatric Renal Transplant Recipients in a Prospective Study: Lessons Learned and Model Improvement.
Louise M AndrewsBrenda C M de WinterElisabeth A M CornelissenHuib de JongDennis A HesselinkMichiel F SchreuderRoger J M BrüggemannTeun van GelderKarlien CransbergPublished in: Clinical pharmacokinetics (2021)
The weight-normalized starting dose of tacrolimus should be higher in patients with a lower bodyweight and in those who are cytochrome P450 3A5 expressers.
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