Targeting BMI-1 to deplete antibody-secreting cells in autoimmunity.

Jack PolmearLauren HailesMoshe OlshanskyMaureen RischmuellerElan L'Estrange-StranieriAnne L FletcherMargaret L HibbsVanessa L BryantKim L Good-Jacobson

Published in: Clinical & translational immunology (2023)

These data provide evidence that inhibiting BMI-1 can deplete ASC in a variety of contexts and thus BMI-1 is a viable therapeutic target for antibody-mediated autoimmune diseases.

Keyphrases

body mass index
weight gain
induced apoptosis
signaling pathway
cell cycle arrest
electronic health record
big data
physical activity
cell proliferation
nlrp inflammasome
drug delivery
celiac disease
deep learning