Epicardial HDAC3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway.
Jihyun JangGuang SongSarah M PettitQinshan LiXiaosu SongChen-Leng CaiSunjay KaushalDeqiang LiPublished in: Circulation research (2022)
Our findings reveal a critical signaling pathway in which epicardial HDAC3 promotes compact myocardial growth by stimulating FGF9 and IGF2 through repressing miR-322 or miR-503, providing novel insights in elucidating the etiology of congenital heart defects and conceptual strategies to promote myocardial regeneration.