Serum creatine kinase and creatinine in adult spinal muscular atrophy under nusinersen treatment.
Maren FreigangClaudia D WursterTim HagenackerBenjamin StolteMarkus WeilerChristoph KammOlivia Schreiber-KatzAlma OsmanovicSusanne PetriAlexander KowskiThomas MeyerJan C KochIsabell CordtsMarcus DeschauerPaul LingorElisa AustDaniel PetzoldAlbert C LudolphBjörn FalkenburgerAndreas HermannRené GüntherPublished in: Annals of clinical and translational neurology (2021)
Serum creatine kinase activity and serum creatinine concentration reflect disease severity of spinal muscular atrophy and are promising biomarkers to assess patients with spinal muscular atrophy during disease course and to predict treatment response. The decrease of creatine kinase activity, combined with the tendency of creatinine concentration to increase during nusinersen treatment, suggests reduced muscle mass wasting with improved muscle energy metabolism.