Chronic Inorganic Nitrate Administration Increases the Expression of Genes Involved in the Browning of Gonadal Adipose Tissue in Ovariectomized Rats.
Nasibeh YousefzadehSajjad JeddiAsghar GhasemiPublished in: Endocrine, metabolic & immune disorders drug targets (2024)
In OVX rats, chronic nitrate administration increased gene and protein levels of UCP-1, PGC-1945;, and PPAR-947; in GAT, indicating the anti-obesity effects of nitrate are partially mediated by the white adipose tissue (WAT) browning. Moreover, the stimulatory effect of inorganic nitrate on the WAT browning in OVX rats was associated with blunting the OVXinduced NO deficiency in GAT.
Keyphrases
- adipose tissue
- insulin resistance
- nitric oxide
- high fat diet induced
- drinking water
- high fat diet
- skeletal muscle
- metabolic syndrome
- type diabetes
- binding protein
- genome wide
- gene expression
- weight loss
- weight gain
- physical activity
- transcription factor
- copy number
- small molecule
- drug induced
- protein protein
- perovskite solar cells