Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway.

Xiao-Cui ChenDan WuHong-Luan WuHui-Yuan LiChen YangHong-Yong SuZe-Jian LiuXiao-Rong HuangXing LuLi-Feng HuangShao-Ping ZhuQing-Jun PanNing AnHua-Feng Liu

Published in: Lupus science & medicine (2022)

Metformin alleviated kidney injury in LN though suppressing renal necroptosis and inflammation via the AMPK/STAT3 pathway.

Keyphrases

skeletal muscle
cell proliferation
systemic lupus erythematosus
oxidative stress
signaling pathway
protein kinase
disease activity
high fat diet induced
type diabetes
adipose tissue
insulin resistance
metabolic syndrome