Targeted metabolomics identifies accurate CSF metabolite biomarkers for the differentiation between COVID-19 with neurological involvement and CNS infections with neurotropic viral pathogens.

Frieder NeuSandra NaySven SchuchardtFrank KlawonnThomas SkripuletzKurt-Wolfram SuehsFrank Pessler

Published in: Journal of translational medicine (2024)

The results suggest that CNS metabolite responses in neuro-COVID differ fundamentally from viral CNS infections and aseptic neuroinflammation and may be used to discover accurate diagnostic biomarkers in CSF and to gain insights into differences in pathophysiology between neuro-COVID, viral CNS infections and aseptic neuroinflammation.

Keyphrases

sars cov
coronavirus disease
blood brain barrier
respiratory syndrome coronavirus
cerebral ischemia
traumatic brain injury
lipopolysaccharide induced
lps induced
high resolution
mass spectrometry
genome wide
gram negative
cerebrospinal fluid
gene expression
multidrug resistant
brain injury
drug delivery