Unveiling the Role of Tryptophan 2,3-Dioxygenase in the Angiogenic Process.
Marta CecchiCecilia AnceschiAngela SilvanoMaria Luisa ConiglioAurora ChinniciLucia MagnelliAndrea LapucciAnna LaurenzanaAstrid ParentiPublished in: Pharmaceuticals (Basel, Switzerland) (2024)
HUVECs and ECFCs express the key enzymes of the kynurenine pathway. Significantly, TDO emerges as a pivotal player in in vitro proliferation and capillary morphogenesis, suggesting a potential pathophysiological role in angiogenesis beyond its well-known immunomodulatory effects.