CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene-Gene Interactions Are Associated with Restenosis after Coronary Stenting.

In the present study, we evaluated the association of the BAT1 , NFKBIL , LTA , and CASP1 single nucleotide polymorphisms and the gene-gene interactions with risk of developing restenosis after coronary stenting. The allele and genotype determination of the polymorphisms ( BAT1 rs2239527 C / G , NFKBIL1 rs2071592 T / A , LTA rs1800683 G / A , CASP1 rs501192 A / G , and CASP1 rs580253 A / G ) were performed by 5'exonuclease TaqMan assays in 219 patients: 66 patients with restenosis and 153 without restenosis. The distribution of rs2239527 C / G , rs2071592 T / A , and rs1800683 G / A polymorphisms was similar in patients with and without restenosis. Nonetheless, under recessive (OR = 2.73, pC Res = 0.031) and additive models (OR = 1.65, pC Add = 0.039), the AA genotype of the rs501192 A / G polymorphism increased the restenosis risk. Under co-dominant, dominant, recessive, and additive models, the AA genotype of the rs580253 A/G was associated with a high restenosis risk (OR = 5.38, pC Co-Dom = 0.003; OR = 2.12, pC Dom = 0.031; OR = 4.32, pC Res = 0.001; and OR = 2.16, 95%CI: 1.33-3.52, pC Add = 0.001, respectively). In addition, we identified an interaction associated with restenosis susceptibility: BAT1-NFKBIL1-LTA-CASP1 (OR = 9.92, p < 0.001). In summary, our findings demonstrate that the rs501192 A / G and rs580253 A / G polymorphisms, as well as the gene-gene interactions between BAT1-NFKBIL1-LTA-CASP1 , are associated with an increased restenosis risk after coronary stenting.