Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination.

Johanna E Huber Julia Ahlfeld Magdalena K Scheck Magdalena ZauchaKlaus WitterLisa Lehmann Hadi Karimzadeh Michael PritschMichael HoelscherFrank von SonnenburgAndrea Dick Giovanna Barba-Spaeth Anne B Krug Simon Rothenfußer Dirk Baumjohann

Published in: Clinical & translational immunology (2020)

In summary, we describe detailed cTfh kinetics during YF-17D vaccination. Our results suggest that cTfh expansion and polarisation can serve as a prognostic marker for vaccine success. These insights may be leveraged in the future to improve current vaccine design and strategies.

Keyphrases

single cell
regulatory t cells
dendritic cells
stem cells
immune response
aqueous solution