Evaluation of integrase resistance in individuals who failed a regimen containing dolutegravir in French and Italian clinical settings.

Daniele ArmeniaMaria M SantoroCharlotte CharpentierAda BertoliFederica ForbiciVincent CalvezDiane DescampsFrancesca Ceccherini-SilbersteinAnne-Genevieve MarcelinPhilippe Flandre

Published in: The Journal of antimicrobial chemotherapy (2023)

In a large set of individuals failing dolutegravir in real-life, INSTI resistance was low and mainly related to previous first-generation INSTI exposure. Surveillance of integrase resistance remains crucial to preserve efficacy of INSTI class in the future.

Keyphrases

public health
hiv infected patients
antiretroviral therapy