Role of Pellino-1 in Inflammation and Cardioprotection following Severe Sepsis: A Novel Mechanism in a Murine Severe Sepsis Model † .

Mahesh ThirunavukkarasuSantosh SwaminathanAndrew KemerleySeetur R PradeepSue Ting LimDiego AccorsiRickesha WilsonJacob CampbellIbnalwalid SaadSiu-Pok YeeJ Alexander PalestyDavid W McFaddenNilanjana Maulik

Published in: Cells (2023)

Our results indicate that overexpression of Peli1 is a novel approach that not only preserved cardiac function but reduced inflammatory markers and apoptosis following severe sepsis in a murine genetic model.

Keyphrases

acute kidney injury
septic shock
intensive care unit
oxidative stress
early onset
drug induced
endoplasmic reticulum stress
cell proliferation
gene expression
copy number
signaling pathway