Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model.
Xiaobo LiWenxiu YuYunqian GuanHaiqiang ZouZhaohui LiangMin HuangRenchao ZhaoChunsong ZhaoZhenhua RenZhiguo ChenPublished in: Stem cells international (2020)
The MSC-mediated increase in IGF-1 levels in the infarct cortex mainly derives from two sources, astrocytes in brain and blood plasma in periphery. Manipulating the IGF-1 level in the peripheral circulation may lead to a higher level of IGF-1 in brain, which could be conducive to recovery at the early stage of dMCAO.