Genome-wide methylation profiling of diagnostic tumor specimens identified DNA methylation markers associated with metastasis among men with untreated localized prostate cancer.

Chun R Chao Jeff M Slezak Kimberly D Siegmund Kimberly L Cannavale Yu-Hsiang Shu Gary W Chien Xu-Feng Chen Feng Shi Nan Song Stephen K Van den Eeden Jiaoti Huang

Published in: Cancer medicine (2023)

Our findings do not support the use of these markers to improve clinical risk prediction. The methylation markers identified may inform novel hypothesis in the roles of these genetic regions in metastasis development.

Keyphrases

genome wide
dna methylation
prostate cancer
copy number
gene expression
radical prostatectomy
middle aged