Are paternal or grandmaternal age associated with higher probability of trisomy 21 in offspring? A population-based, matched case-control study, 1995-2015.

Karen C SchliepMarcia L FeldkampHeidi A HansonMichael HollingshausAlison FraserKen R SmithKatherine A PanushkaMichael W Varner

Published in: Paediatric and perinatal epidemiology (2020)

Maternal age is an important risk factor for trisomy 21 offspring; however, this population-based study shows that that young paternal age is also associated with trisomy 21, after taking into account maternal age and race/ethnicity.

Keyphrases

high fat diet
type diabetes
birth weight
adipose tissue
body mass index