Effect of chronic kidney disease induced calcification on peripheral vascular perfusion using near-infrared spectroscopic imaging.
Daniela LeizaolaValentina DargamKevin LeivaHaniyeh AlirezaeiJoshua HutchesonAnuradha GodavartyPublished in: Biomedical optics express (2023)
Low-cost techniques that can detect the presence of vascular calcification (VC) in chronic kidney disease (CKD) patients could improve clinical outcomes. In this study, we established a near-infrared spectroscopy-based imaging technique to determine changes in peripheral hemodynamics due to CKD-induced VC. Mice were fed a high-adenine diet with either normal or high levels of phosphate to induce CKD with and without VC, respectively. The mice tail was imaged to evaluate hemodynamic changes in response to occlusion. The rate of change in oxyhemoglobin in response to occlusion showed a statistically significant difference in the presence of VC in the mice.
Keyphrases
- chronic kidney disease
- end stage renal disease
- low cost
- high fat diet induced
- high glucose
- high resolution
- diabetic rats
- ejection fraction
- drug induced
- peritoneal dialysis
- type diabetes
- newly diagnosed
- magnetic resonance imaging
- computed tomography
- endothelial cells
- weight loss
- wild type
- metabolic syndrome
- magnetic resonance
- skeletal muscle
- prognostic factors
- patient reported outcomes
- contrast enhanced