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SiO 2 @Au nanoshell-assisted laser desorption/ionization mass spectrometry for coronary heart disease diagnosis.

Yanyan LiHua ZhangJingjing JiangLin ZhaoYun-Bing Wang
Published in: Journal of materials chemistry. B (2023)
Cardiovascular diseases have threatened human health, amongst which coronary heart disease (CHD) is the third most common cause of death. CHD is considered to be a metabolic disease; however, there is little research on the CHD metabolism. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has enabled the development of a suitable nanomaterial that can be used to obtain considerable high-quality metabolic information without complex pretreatment of biological fluid samples. This study combines SiO 2 @Au nanoshells with minute plasma to obtain metabolic fingerprints of CHD. The thickness of the SiO 2 @Au shell was also optimized to maximize the laser desorption/ionization effect. The results demonstrated 84% sensitivity at 85% specificity for distinguishing CHD patients from controls in the validation cohort.
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