SiO 2 @Au nanoshell-assisted laser desorption/ionization mass spectrometry for coronary heart disease diagnosis.
Yanyan LiHua ZhangJingjing JiangLin ZhaoYun-Bing WangPublished in: Journal of materials chemistry. B (2023)
Cardiovascular diseases have threatened human health, amongst which coronary heart disease (CHD) is the third most common cause of death. CHD is considered to be a metabolic disease; however, there is little research on the CHD metabolism. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has enabled the development of a suitable nanomaterial that can be used to obtain considerable high-quality metabolic information without complex pretreatment of biological fluid samples. This study combines SiO 2 @Au nanoshells with minute plasma to obtain metabolic fingerprints of CHD. The thickness of the SiO 2 @Au shell was also optimized to maximize the laser desorption/ionization effect. The results demonstrated 84% sensitivity at 85% specificity for distinguishing CHD patients from controls in the validation cohort.
Keyphrases
- mass spectrometry
- human health
- liquid chromatography
- sensitive detection
- risk assessment
- end stage renal disease
- high performance liquid chromatography
- cardiovascular disease
- gas chromatography
- capillary electrophoresis
- high resolution
- ejection fraction
- reduced graphene oxide
- chronic kidney disease
- newly diagnosed
- multiple sclerosis
- climate change
- magnetic nanoparticles
- optical coherence tomography
- prognostic factors
- ms ms
- patient reported outcomes
- simultaneous determination
- health information