Coagulation and Endothelial Dysfunction Associated with NAFLD: Current Status and Therapeutic Implications.
Doris OgrestaAnna MrzljakMaja Cigrovski Maja Cigrovski BerkovicInes Bilić ĆurčićSanja Stojsavljevic-ShapeskiLucija Virovic-JukicPublished in: Journal of clinical and translational hepatology (2022)
Non-alcoholic fatty liver disease (NAFLD) is closely related to insulin resistance, type 2 diabetes mellitus and obesity. It is considered a multisystem disease and there is a strong association with cardiovascular disease and arterial hypertension, which interfere with changes in the coagulation system. Coagulation disorders are common in patients with hepatic impairment and are dependent on the degree of liver damage. Through a review of the literature, we consider and discuss possible disorders in the coagulation cascade and fibrinolysis, endothelial dysfunction and platelet abnormalities in patients with NAFLD.
Keyphrases
- insulin resistance
- cardiovascular disease
- arterial hypertension
- type diabetes
- metabolic syndrome
- current status
- adipose tissue
- high fat diet induced
- weight loss
- oxidative stress
- skeletal muscle
- high fat diet
- glycemic control
- cardiovascular risk factors
- polycystic ovary syndrome
- weight gain
- body mass index
- drug induced