The Protective Effect of Dabigatran and Rivaroxaban on DNA Oxidative Changes in a Model of Vascular Endothelial Damage with Oxidized Cholesterol.

Ewelina Wozniak Marlena Broncel Bożena Bukowska Paulina Gorzelak-Pabiś

Published in: International journal of molecular sciences (2020)

Observed changes strongly suggest that the tested anticoagulants induced indirect repair of DNA by inhibiting ROS production. Furthermore, dabigatran appears to have a higher antioxidant activity than rivaroxaban.

Keyphrases

atrial fibrillation
circulating tumor
low density lipoprotein
venous thromboembolism
cell free
single molecule
pulmonary embolism
high glucose
endothelial cells
diabetic rats
oxidative stress
cell death
signaling pathway
dna damage
nucleic acid
drug induced
reactive oxygen species
circulating tumor cells