JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function.

Oriol BusquetsTriana Espinosa-JiménezMiren EttchetoJordi OlloquequiMònica BullóEva CarroJosé Luis CanteroGemma CasadesúsJaume FolchEster VerdaguerCarme AuladellAntonio Camins Espuny

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Downregulation of JNK3 does not seem to be a suitable target for the modulation of energetic-cognitive dysregulations while loss of function of JNK1 seems to promote a good metabolic-cognitive profile, just like resistance to the negative effects of chronic feeding with HFD.

Keyphrases

signaling pathway
cell death
induced apoptosis
high fat diet
endoplasmic reticulum stress
metabolic syndrome
adipose tissue