VEGF-C induced by TGF- β1 signaling in gastric cancer enhances tumor-induced lymphangiogenesis.

Kyung Ho PakKi Cheong ParkJae Ho Cheong

Published in: BMC cancer (2019)

Smad-dependent and -independent TGF-β1 pathways induce VEGF-C, which make lymphangiogenesis around tumor. These findings suggest that TGF-β might be a potential therapeutic target for preventing gastric cancer progression and dissemination.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
vascular endothelial growth factor
endothelial cells
high glucose
diabetic rats
drug induced
oxidative stress
signaling pathway
human health
climate change