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Alcohol and colorectal cancer risk, subclassified by mutational signatures of DNA mismatch repair deficiency.

Ai-Ping FangTomotaka UgaiCarino GurjaoRong ZhongZhenhua LiuXinyuan ZhangPeilu WangJonathan NowakMolin WangMarios GiannakisShuji OginoXuehong ZhangEdward L Giovannucci
Published in: Journal of the National Cancer Institute (2024)
High alcohol consumption was associated with an increased incidence of CRC containing higher contributions of c-dMMRb/SBS26, suggesting that alcohol consumption may be involved in colorectal carcinogenesis through the DNA mismatch repair pathway.
Keyphrases
  • alcohol consumption
  • circulating tumor
  • cell free
  • single molecule
  • nucleic acid
  • gene expression
  • replacement therapy