Determination of intracellular tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots for pre-exposure prophylaxis adherence.

Kiyoto TsuchiyaYoshiharu HayashiShoraku RyuHieu Trung TranMisao TakanoKazuko TanakaDaisuke MizushimaShinichi OkaHiroyuki GatanagaAkinobu Hamada

Published in: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (2024)

A multiplex LC-MS/MS method was successfully developed for DBS, which can be useful for monitoring the levels of TFV-DP and FTC-TP in individuals receiving PrEP.

Keyphrases

men who have sex with men
deep brain stimulation
solid phase extraction
high throughput
molecularly imprinted
real time pcr
antiretroviral therapy
reactive oxygen species
mass spectrometry