Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases.

Richard S P HuangLukas HarriesBrennan DeckerMatthew C HiemenzKarthikeyan MurugesanJames CreedenKhaled TolbaLaura P StabileShakti H RamkissoonTimothy F BurnsJeffrey S Ross

Published in: The oncologist (2022)

Herein, we defined the clinicopathologic, genomic, and biomarker landscape of a large cohort of patients with NSCLC-BM which can help inform study design of future clinical studies for patients with NSCLC with BM. In certain clinical situations, metastatic NSCLC brain tissue or cerebral spinal fluid specimens may be needed to fully optimize personalized treatment.

Keyphrases

brain metastases
small cell lung cancer
copy number
single cell
advanced non small cell lung cancer
spinal cord
subarachnoid hemorrhage
cerebral ischemia
combination therapy
functional connectivity
ultrasound guided
fine needle aspiration
cerebral blood flow