Significance of Glypican-3 in Early Detection of Hepatocellular Carcinoma in Cirrhotic Patients.
Ahmed M TahonMagdy Z El-GhanamSamy ZakyTarek Mostafa EmranAli M BersyFathiya El-RaeyElsayed A ZAmr M El KharsawyDina JoharPublished in: Journal of gastrointestinal cancer (2020)
The combined serum AFP and GPC3 significantly increased the sensitivity of HCC diagnosis. Although GPC3 is better than AFP in diagnosis of HCC, it still lacks the 100% sensitivity and specificity because some patients have negative or normal level of GPC3 (below the cutoff point 1.5 ng/ml) despite being diagnosed by triphasic CT.