Diastereoselective Construction of Indole-Bridged Chroman Spirooxindoles through a TfOH-Catalyzed Michael Addition-Inspired Cascade Reaction.

Jiaomei GuoXuguan BaiQi-Lin WangZhanwei Bu

Published in: The Journal of organic chemistry (2018)

The first highly diastereoselective Michael addition/condensation/Friedel-Crafts alkylation cascade reaction of 3-indolyl-substituted oxindoles with ortho-hydroxychalcones was established, which afforded a wide range of polycyclic indole-bridged chroman spirooxindoles with novel and complex scaffolds in moderate to excellent yields.

Keyphrases

molecular docking
high intensity
room temperature
tissue engineering
electron transfer