Gene expression profiling of prostate tissue identifies chromatin regulation as a potential link between obesity and lethal prostate cancer.

Ericka M EbotTravis GerkeDavid P LabbéJennifer A SinnottGiorgia ZadraJennifer R RiderSvitlana TyekuchevaKathryn M WilsonRachel S KellyIrene M ShuiMassimo LodaPhilip W KantoffStephen FinnMatthew G Vander HeidenMyles BrownEdward L GiovannucciLorelei A Mucci

Published in: Cancer (2017)

This study improves our understanding of the biology of aggressive prostate cancer and identifies a potential mechanistic link between obesity and prostate cancer death that warrants further study. Cancer 2017;123:4130-4138. © 2017 American Cancer Society.

Keyphrases

prostate cancer
gene expression
radical prostatectomy
metabolic syndrome
type diabetes
genome wide
insulin resistance
papillary thyroid
dna methylation
weight gain
transcription factor
high fat diet induced
dna damage
squamous cell carcinoma
single cell
body mass index
skeletal muscle